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Comparison of the haemodynamic effects of the selective bradycardic agent UL‐FS 49, with those of propranolol during treadmill exercise in dogs
Author(s) -
Krumpl G.,
Winkler M.,
Schneider W.,
Raberger G.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11499.x
Subject(s) - propranolol , hemodynamics , medicine , treadmill , cardiology , anesthesia
1 To clarify whether the bradycardic agent UL‐FS 49 exhibits a positive inotropic effect even in the absence of improvement in regional myocardial function of an underperfused myocardial area, this study was undertaken in dogs with unimpaired coronary flow. 2 We also investigated the haemodynamic and functional effects of the negative chronotropic and inotropic β‐adrenoceptor blocker propranolol. 3 UL‐FS 49 did not depress total or regional myocardial performance. Moreover, an increase in positive left ventricular dp/dt max at rest suggests a positive inotropic effect of UL‐FS 49. 4 Propranolol, in contrast to UL‐FS 49, led to a marked reduction in positive dp/dt max , stroke volume and systolic wall thickening at rest and during exercise. Additionally, propranolol decreased the exercise values of cardiac output, left ventricular work and left ventricular power to a far greater extent than UL‐FS 49. 5 In contrast to propranolol, the selective bradycardic agent UL‐FS 49 did not decrease total or regional ventricular performance and caused less reduction in cardiodynamic parameters during exercise. 6 These results suggest that patients with moderate coronary insufficiency or patients with coronary vessel disease and mild left ventricular failure may attain a higher exercise limit under selective bradycardia with UL‐FS 49 in comparison to that possible with a β‐adrenoceptor antagonist, such as propranolol.