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4‐Hydroxy‐2‐methyl‐4‐phenyl‐1,2,3,4‐tetrahydroisoquinoline (PI‐OH): a new potentiator of sympathomimetic amines on the rat anococcygeus muscle
Author(s) -
Ishida Y.,
Koga N.,
Nanbu T.,
Kihara M.,
Kobayashi S.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11495.x
Subject(s) - nomifensine , desipramine , potentiator , chemistry , postsynaptic potential , stimulation , inhibitory postsynaptic potential , agonist , pharmacology , stereochemistry , endocrinology , dopamine , biochemistry , biology , antidepressant , dopaminergic , receptor , hippocampus
1 The potentiating effects of racemic 4‐hydroxy‐2‐methyl‐4‐phenyl‐1,2,3,4‐tetrahydroisoquinoline (PI‐OH), cocaine, desipramine and nomifensine on the concentration‐response curves of the rat anococcygeus muscle to noradrenaline (NA) and field stimulation were examined. 2 PI‐OH and cocaine concentration‐dependently potentiated the responses of anococcygeus muscle to NA and field stimulation, but the activity of PI‐OH was stronger than that of cocaine on both responses. 3 At high concentrations the potentiating activities of desipramine and nomifensine were less, a fact that was explained by their postsynaptic inhibitory properties; the actions of nomifensine and desipramine as antagonists against NA were competitive and non‐competitive, respectively. 4 It is concluded that PI‐OH may be an ideal potentiator of the response to NA in adrenergically‐innervated tissues because it has no side effects such as postsynaptic inhibition.