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The potential anxiolytic activity of GR38032F, a 5‐HT 3 ‐receptor antagonist
Author(s) -
Jones B.J.,
Costall B.,
Domeney A.M.,
Kelly M.E.,
Naylor R.J.,
Oakley N.R.,
Tyers M.B.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11489.x
Subject(s) - anxiolytic , marmoset , antagonist , pharmacology , anticonvulsant , sedative , receptor antagonist , sedation , psychology , receptor , chemistry , medicine , neuroscience , biology , epilepsy , paleontology
1 The highly selective 5‐HT 3 ‐receptor antagonist, GR38032F, has been tested in five animal models predictive for anxiolytic activity. 2 In the social interaction test in the rat and in a light/dark exploration test in the mouse, GR38032F dose‐dependently released suppressed behaviour without modifying locomotor activity. 3 In the cynomolgus monkey and the marmoset, GR38032F reduced anxiety‐related symptoms without causing sedation. In the marmoset, the effects were clearly dose‐related. 4 GR38032F did not have any detectable activity in the water‐lick conflict test in the rat. 5 We conclude that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity.