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Inhibitory regulation by co‐released peptides of catecholamine secretion by the canine adrenal medulla
Author(s) -
Critchley J.A.J.H.,
MacLean Margaret R.,
Ungar A.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11445.x
Subject(s) - medicine , catecholamine , endocrinology , adrenal medulla , stimulation , adrenal gland , chemistry , enalapril , norepinephrine , splanchnic nerves , captopril , dopamine , angiotensin converting enzyme , blood pressure
1 We have stimulated the peripheral end of the cut left splanchnic nerve in anaesthetized dogs while collecting the venous effluent of the left adrenal gland for catecholamine estimation. 2 With low frequency stimulation the resting output of catecholamines was inhibited but at high frequencies it was augmented. 3 The inhibition of catecholamine output by low frequency stimulation was reversed by opiate antagonists (naloxone and nalmefene) but enhanced by angiotensin converting enzyme inhibitors (captopril and enalapril).