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Central inhibition by γ‐aminobutyric acid of the release of vasopressin by carbachol in the rat
Author(s) -
Chowdrey H.S.,
Bisset G.W.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11441.x
Subject(s) - vasopressin , carbachol , bicuculline , muscimol , medicine , endocrinology , picrotoxin , chemistry , inhibitory postsynaptic potential , hypothalamus , antidiuretic , gamma aminobutyric acid , gaba receptor antagonist , biology , antagonist , gabaa receptor , stimulation , receptor
1 γ‐Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.) in the water‐loaded rat under ethanol anaesthesia. 2 The inhibitory effect of GABA was mimicked by muscimol and 3‐amino‐1‐propane sulphonic acid (3‐APS) and blocked by bicuculline. 3 GABA injected i.v. or into the cisterna magna (i.cist.) did not inhibit the release of vasopressin by carbachol injected i.c.v. 4 The results suggest a role for GABA as a putative inhibitory transmitter in the hypothalamo‐neurohypophysial system, acting directly on the supraoptic or paraventricular nuclei in the anterior hypothalamus.