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Effects of chronic oral administration of the antidepressants, desmethylimipramine and zimelidine on rat cortical GABA B binding sites: a comparison with 5‐HT 2 binding site changes
Author(s) -
Cross Jacqueline A.,
Horton Roger W.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11438.x
Subject(s) - gabab receptor , binding site , pharmacology , chemistry , desipramine , antidepressant , endocrinology , medicine , hippocampus , receptor , agonist , biochemistry
1 The effects of chronic oral administration of desmethylimipramine (DMI) or zimelidine (1.25 and 5 mg kg −1 twice daily for 21 days) were studied on rat whole cortical γ‐aminobutyric acid B (GABA B ) binding sites. No changes in receptor affinity or number were found with either drug. 2 A subsequent study of GABA B binding sites using higher doses of these drugs (5 and 10 mg kg −1 ) and rat frontal cortex was also without effect, when investigated 24 h after termination of drug administration or 72 h after DMI administration (5 mg kg −1 ). 3 The number of frontal cortical 5‐hydroxytryptamine 2 (5‐HT 2 ) binding sites was significantly and dose‐dependently decreased after both drugs, whereas the number of hippocampal 5‐HT 2 binding sites was not significantly altered after either drug. 4 As the number of frontal cortical GABA B binding sites was unaltered whereas the number of 5‐HT 2 binding sites was significantly decreased under identical study conditions, it may be concluded that the effects of antidepressant administration upon GABA B binding sites is a less consistent observation than their effects on 5‐HT 2 binding sites.