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Interactions of the imidazodiazepine Ro 15–4513 with chemical convulsants
Author(s) -
Lister Richard G.,
Nutt David J.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11423.x
Subject(s) - convulsant , picrotoxin , convulsants , chemistry , inverse agonist , bicuculline , pharmacology , benzodiazepine , strychnine , gabaa receptor , anticonvulsant , convulsion , seizure threshold , gaba receptor antagonist , agonist , receptor , epilepsy , medicine , biochemistry , psychiatry
1 The proconvulsant effects of the imidazodiazepine Ro 15–4513, were investigated in mice by use of intravenous infusion of a variety of convulsant drugs. 2 Dose‐response and time course studies of Ro 15–4513 against γ‐aminobutyric acid (GABA) antagonists were performed. On the basis of these studies a maximally effective dose of 5 mg kg −1 was administered 5 min before the determination of seizure thresholds in subsequent experiments. 3 Ro 15–4513 (5 mg kg −1 ) significantly lowered seizure thresholds to pentylenetetrazole, bicuculline and the convulsant benzodiazepine Ro 5–3663, but failed to alter seizure thresholds to picrotoxin, strychnine, caffeine and quipazine. 4 Ro 15–4513 significantly raised seizure threshold to the benzodiazepine receptor inverse agonist methyl 6,7‐dimethoxy‐4 ethyl‐β‐carboline‐3‐carboxylate (DMCM). 5 These results are discussed in relation to other studies investigating the proconvulsant and alcohol‐antagonizing effects of Ro 15–4513.