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Studies on the effects of viprostol in isolated small blood vessels and thoracic aorta of the rat
Author(s) -
Lai Fong M.,
Tanikella Tarak,
Cobuzzi Agnes,
Cervoni Peter
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb10318.x
Subject(s) - contraction (grammar) , basilar artery , thoracic aorta , aorta , medicine , vasodilation , artery , mesenteric arteries , anatomy , anesthesia , chemistry
1 The effects of viprostol, prostaglandin E 2 (PGE 2 ) and nitroglycerin were studied in basilar artery, small mesenteric artery and the vein parallel to it as well as thoracic aorta of the rat. 2 In KCl‐contracted basilar artery, viprostol produced a concentration‐related biphasic response, contraction at concentrations < 3 × 10 −6 m and relaxation at concentrations >3 × 10 −6 m . PGE 2 produced a concentration‐related contraction while nitroglycerin produced a concentration‐related relaxation. 3 In KCl‐contracted small mesenteric artery, viprostol produced a biphasic response which was similar to that in the basilar artery. PGE 2 produced a contraction and nitroglycerin produced relaxation in a concentration‐dependent manner. 4 In KCl‐contracted small mesenteric vein, in contrast to basilar and mesenteric artery, viprostol produced only a concentration‐related relaxation in the range of 1 × 10 −6 to 1 × 10 −4 m . PGE 2 produced a contraction and nitroglycerin produced a concentration‐related relaxation. 5 In KCl‐contracted thoracic aorta, PGE 2 produced a biphasic response, relaxation at concentrations < 3 × 10 −7 m and a concentration‐related contraction at concentrations > 3 × 10 −7 m. Viprostol only produced a concentration‐related contraction at concentrations >1 × 10 −6 m , which was significantly less in magnitude than the contraction produced by PGE 2 . Nitroglycerin produced a concentration‐related relaxation as seen in the small vessels. 6 In conclusion, the present data demonstrate that viprostol is a vasorelaxant agent which effectively dilates KCl‐contracted basilar, small mesenteric artery and vein, but not the thoracic aorta of rat. The potent antihypertensive action of viprostol is probably due to its relaxant effect on the small arteries and veins but not on the large conduit artery.