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Pentoxifylline does not reduce infarct size in a canine model of acute myocardial infarction
Author(s) -
Campbell Colin A.,
Clavenna Carl F.,
Wynne Joshua,
Kloner Robert A.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb10314.x
Subject(s) - pentoxifylline , medicine , myocardial infarction , blood flow , infarction , blood pressure , necrosis , coronary occlusion , fissipedia , occlusion , cardiology , hemodynamics , anesthesia
1 The effect of the haemorrheological agent pentoxifylline was investigated in a canine model of acute myocardial infarction, induced by occlusion of the left anterior descending coronary for 6 h. Thirty minutes post‐occlusion the dogs were randomized to receive either distilled water or pentoxifylline (0.3 mg kg −1 min −1 for 1 h followed by 0.15 mg kg −1 min −1 for 4.5 h) intravenously. 2 At 6 h post‐occlusion the in vivo area at risk was determined with monastral blue dye and the area of necrosis was determined with triphenyltetrazolium chloride. The area at risk was 16.5 ± 1.3% in the control group ( n = 10) and 17.2 ± 1.8% in the pentoxifylline treated group ( n = 10; NS). The area of necrosis was 12.3 ± 1.9% in the control group and 11.9 ± 2.2% in the pentoxifylline treated group (NS). The area of necrosis expressed as a percentage of the area at risk was 69.3 ± 7.7% in the control group and 63.6 ± 7.4% in the pentoxifylline treated group (NS). 3 Pentoxifylline had no significant effects on heart rate, systolic or diastolic blood pressure. Regional myocardial blood flow, measured by the radioactive microsphere technique, was not significantly different between the groups. 4 Thus, pentoxifylline does not reduce infarct size in this model of acute myocardial infarction and does not enhance coronary collateral blood flow.