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Changes in central GABAergic function following acute and repeated stress
Author(s) -
Losada Matilde E. Otero
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb10302.x
Subject(s) - glutamate decarboxylase , gabaergic , striatum , cerebral cortex , gamma aminobutyric acid , endocrinology , medicine , neuroscience , cortex (anatomy) , central nervous system , chemistry , biology , enzyme , biochemistry , inhibitory postsynaptic potential , receptor , dopamine
1 The function of γ‐aminobutyric acid (GABA)ergic systems in response to acute and repeated stressful manipulations was evaluated in both the corpus striatum and frontal cerebral cortex of the rat. 2 In the corpus striatum the activity of the synthetic enzyme for GABA (glutamic acid decarboxylase, GAD) and the levels of GABA were reduced by acute immobilization stress (1 h). GABA turnover was reduced only by acute cold stress (3 h, 4°C). 3 In the frontal cerebral cortex no changes were observed after acute stressful manipulations, but repeated stress (0.5 h immobilization per day for 14 days) enhanced both GAD activity and GABA turnover, and reduced GABA levels. 4 In conclusion, it would appear that the GABAergic system in the corpus striatum of the rat is most sensitive to acute stress and that the system in the frontal cerebral cortex area is preferentially responsive to chronic stress. It is speculated that the cortical GABAergic system is responsible for adaptive responses to the adverse conditions prevailing during chronic stress.