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Interactions of amiodarone with digoxin in rats
Author(s) -
Braunschweig Jean,
Stäubli Max,
Studer Hugo
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11356.x
Subject(s) - amiodarone , digoxin , medicine , endocrinology , cardiac glycoside , distribution (mathematics) , volume of distribution , chemistry , pharmacokinetics , heart failure , ouabain , atrial fibrillation , mathematical analysis , mathematics , organic chemistry , sodium
1 The influence of oral amiodarone treatment on the blood and tissue concentrations of digoxin was investigated in the anaesthetized rat by use of unlabelled and [ 3 H]‐digoxin. 2 Amiodarone diminished the total body clearance and the apparent volume of digoxin distribution by 60%. This reduction was due to a 50% reduction of the hepatobiliary clearance, whereas the renal clearance did not change. 3 Amiodarone treatment increased blood, myocardial and skeletal muscle [ 3 H]‐digoxin concentrations by 200% indicating passive equilibration between blood and these tissues, and resulting in unaltered tissue to blood ratios. In contrast, the liver concentration increased by 70% only and the liver to blood ratio therefore decreased under amiodarone treatment. 4 It is concluded that the hepatobiliary elimination of digoxin is decreased in amiodarone‐treated rats compared to controls and is responsible for the increased levels of blood and tissue glycoside.