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Effect of angiotensin‐converting enzyme inhibitor YS980 on prostaglandin synthesis in rabbit kidney medulla slices
Author(s) -
Fujimoto Yohko,
Wada Kohichiro,
Kaneko Mika,
Fujita Tadashi
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11346.x
Subject(s) - prostaglandin , kidney , chemistry , endocrinology , renal medulla , prostaglandin e , medicine , angiotensin converting enzyme , renin–angiotensin system , prostaglandin e2 , enzyme , enzyme inhibitor , pharmacology , biology , biochemistry , blood pressure
The effect of YS980, an angiotensin‐converting enzyme inhibitor, on the generation of medullary prostaglandins E 2 and F 2α was examined. At concentrations of 0.2 m m and below, YS980 enhanced prostaglandin F 2α synthesis at the expense of prostaglandin E 2 . At concentrations of 0.4 m m or more, YS980 inhibited synthesis of both prostaglandins E 2 and F 2α markedly. These results suggest that YS980 has the potential to modulate prostaglandins E 2 and F 2α synthesis by the kidney and that this effect may represent some pharmacological action of the drug.