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Increase by oestrogen of calcium entry and calcium channel density in uterine smooth muscle
Author(s) -
Batra S.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11335.x
Subject(s) - nitrendipine , myometrium , endocrinology , medicine , ovariectomized rat , calcium , calcium channel , chemistry , voltage dependent calcium channel , endometrium , estrogen , uterus , in vivo , biology , microbiology and biotechnology
1 The effect of in vivo oestrogen treatment on both 45 Ca influx in myometrial strips and the kinetics of [ 3 H)‐nitrendipine binding in the isolated plasma membrane (PM) was studied. 2 After four days of continuous oestrogen treatment of ovariectomized rats, 45 Ca influx in both resting (unstimulated) and K‐stimulated myometrium was substantially increased. 3 Oestrogen treatment significantly increased the density in PM of nitrendipine binding sites and also caused a slight and insignificant increase in the affinity for nitrendipine. 4 The data suggest that the increase in Ca entry following oestrogen treatment prol ably results from an increase in calcium channel density.