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Release of endogenous ATP during sympathetic nerve stimulation
Author(s) -
Lew M.J.,
White T.D.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11330.x
Subject(s) - vas deferens , tetrodotoxin , endogeny , stimulation , prazosin , contraction (grammar) , muscle contraction , medicine , endocrinology , chemistry , antagonist , receptor
1 Vas deferens from guinea‐pig was stimulated with a suction electrode and both contractions and release of endogenous ATP monitored 2 Release of ATP was tetrodotoxin‐sensitive and increased when the number of stimuli was increased. 3 Release of ATP was not due to contraction of the muscle and persisted following block of contractions with prazosin and α,β‐methylene ATP. 4 These results indicate that stimulation of the sympathetic nerves in the vas deferens releases endogenous ATP presynaptically, supporting a cotransmitter function for ATP with noradrenaline.