Premium
Effect of cholera toxin on the production of eicosanoids by rat jejunum
Author(s) -
Autore Giuseppina,
Capasso Francesco,
Carlo Giulia,
Mascolo Nicola
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11306.x
Subject(s) - jejunum , cholera toxin , toxin , cholera , biology , chemistry , microbiology and biotechnology , biochemistry
1 Cholera toxin injected i.v. into rats stimulated the production of prostaglandin E 2 (PGE 2 ), leukotriene B 4 (LTB 4 ) and LTC 4 by segments of jejunum, but it had no effect when added to the tissue in vitro.2 Pretreatment of the animals with the compound BW 755C reduced the increased production of PGE 2 , LTB 4 and LTC 4 by i.v. cholera toxin. Pretreatment with indomethacin reduced the production of PGE 2 . 3 These findings are consistent with the hypothesis that arachidonate metabolites are involved in the diarrhoea induced by cholera toxin.