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The protective effects of sulphasalazine against ethanol‐induced gastric damage in rats
Author(s) -
Cho C.H.,
Ogle C.W.,
Sevilla E.L.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11292.x
Subject(s) - mucus , stomach , pepsin , chemistry , ethanol , gastric mucosa , prostaglandin , prostaglandin e2 , gastric acid , medicine , pharmacology , basal (medicine) , endocrinology , biochemistry , biology , enzyme , ecology , insulin
1 The inhibitory action of sulphasalazine on ethanol‐induced gastric damage was studied in rats. 2 Sulphasalazine (62.5 or 125 mg kg −1 , s.c.) did not affect basal gastric acid secretion but increased pepsin output. 3 Ethanol (40% v/v, 10 ml kg −1 , p.o.) produced severe gastric glandular mucosal damage and lessened the stomach emptying rate of resin pellets, but it increased the levels of prostaglandin E 2 (PGE 2 )‐like activity in the glandular mucosa. 4 Sulphasalazine markedly prevented ethanol‐induced damage and significantly elevated gastric wall mucus levels both in basal conditions and in the presence of ethanol. 5 Sulphasalazine caused a small insignificant increase in mucosal PGE 2 levels in both control and ethanol‐treated rats. The drug significantly increased mucosal PGE 2 levels in indomethacin‐treated animals, but did not prevent indomethacin‐induced mucosal damage. 6 Sulphapyridine but not 5‐aminosalicylic acid, constituents of sulphasalazine, showed a similar antilesion action to the parent drug, and prevented gastric wall mucus depletion in ethanol‐treated animals. 7 This study elucidates the protective effects of sulphasalazine against ethanol‐induced gastric lesions. The antagonistic action appears to be mediated, at least partly, through the preservation of gastric wall mucus by sulphapyridine.