Premium
Endothelium and the vasodilator action of rat calcitonin gene‐related peptide (CGRP)
Author(s) -
Grace G.C.,
Dusting G.J.,
Kemp B.E.,
Martin T.J.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11270.x
Subject(s) - calcitonin gene related peptide , acetylcholine , sodium nitroprusside , vasodilation , calcitonin , medicine , endocrinology , chemistry , cyclic guanosine monophosphate , guanosine , endothelium , endothelium derived relaxing factor , vascular smooth muscle , nitric oxide , neuropeptide , biochemistry , biology , smooth muscle , receptor
1 Acetylcholine and rat calcitonin gene‐related peptide (CGRP) produced a relaxation in rat isolated aortic rings which was entirely dependent on the presence of the endothelium. 2 In the absence of any exogenous vasodilator agent, the cyclic guanosine monophosphate (cyclic GMP) content was higher in rings with endothelium than in those without. 3 The vasorelaxation produced by acetylcholine and sodium nitroprusside was accompanied by increases in cyclic GMP in the smooth muscle, whereas that produced by CGRP was not accompanied by cyclic GMP accumulation. 4 Therefore, it appears unlikely that CGRP releases an endothelium‐derived relaxing factor similar to that released by acetylcholine.