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A study of the action of clonidine on secretion from the adrenal medulla in dogs
Author(s) -
Anglade F.,
Tran L. Dang,
Blanquat G.,
Gaillard G.,
MichelDamase C.,
Montastruc J.L.,
Montastruc P.,
Rostin M.,
Tran M.A.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11240.x
Subject(s) - clonidine , catecholamine , adrenal medulla , medicine , endocrinology , adrenal gland , splanchnic nerves , stimulation , heart rate , blood pressure , chloralose , norepinephrine , epinephrine , adrenergic , dopamine , receptor
1 The effects of clonidine on adrenal catecholamine (adrenaline and noradrenaline) secretion were investigated in chloralose‐anaesthetized dogs. 2 Intravenous administration of clonidine (10 and 20 μg kg −1 ) induced a decrease in both adrenal catecholamine secretion rates and cardiovascular parameters (blood pressure and heart rate). In contrast, a dose of 5 μg kg −1 was ineffective. 3 Intracisternal clonidine (in a lower dose of 3 μg kg −1 ) also decreased adrenaline and noradrenaline release from the adrenal gland. 4 Clonidine failed to modify adrenal catecholamine release evoked by electrical stimulation of the splanchnic nerve. 5 These results demonstrate that clonidine decreases adrenaline release from the adrenal gland through a central and not a peripheral mechanism in dogs. This action might contribute to its antihypertensive effects.