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Activation of 5‐HT 3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones
Author(s) -
Akasu T.,
Hasuo H.,
Tokimasa T.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11236.x
Subject(s) - methysergide , depolarization , 5 ht receptor , receptor , serotonin , chemistry , endocrinology , medicine , in vitro , intracellular , biophysics , biology , biochemistry
Intracellular recordings were made from parasympathetic neurones of the rabbit vesical pelvic ganglia maintained in vitro. 5‐Hydroxytryptamine (5‐HT) caused a membrane depolarization which was antagonized by ICS 205–930 ([3α‐tropanyl]‐1H‐indole‐3‐carboxylic acid ester) but not by methysergide. ICS 205–930 caused a parallel shift to the right of the dose‐response curve for 5‐HT. These results suggest that the 5‐HT 3 receptor is involved in the membrane depolarization.