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The actions of the peptides, neuropeptide Y and peptide YY, on the vascular and capsular smooth muscle of the isolated, blood‐perfused spleen of the dog
Author(s) -
Corder R.,
Lowry P.J.,
Withrington P.G.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11232.x
Subject(s) - peptide yy , neuropeptide y receptor , neuropeptide , vascular smooth muscle , chemistry , endocrinology , peptide , medicine , biology , smooth muscle , receptor , biochemistry
1 The two peptides, neuropeptide Y (NPY) and peptide YY (PYY) were compared for potency on the vascular and extravascular smooth muscle of the isolated, blood‐perfused spleen of the dog. 2 The only vascular response to both NPY and PYY was vasoconstriction; the maximum effect was to arrest splenic arterial blood flow completely. 3 On a molar basis both NPY and PYY were significantly more potent ( P < 0.01) as splenic arterial vasoconstrictors than the transmitter noradrenaline (NA). 4 PYY was approximately 7 times more potent as a vasoconstrictor than NPY. 5 In contrast to their potency on the vascular smooth muscle, NPY and PYY were significantly ( P < 0.01) less potent than NA in causing contraction of the splenic capsule. The two peptides were equipotent in eliciting this contraction.