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Endothelium‐derived relaxing factor inhibits in vitro platelet aggregation
Author(s) -
Furlong B.,
Henderson A.H.,
Lewis M.J.,
Smith J.A.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11221.x
Subject(s) - endothelium derived relaxing factor , chemistry , sodium nitroprusside , in vitro , thromboxane a2 , platelet , pharmacology , superoxide , endothelium , superoxide dismutase , biochemistry , biophysics , nitric oxide , endocrinology , medicine , enzyme , biology , receptor , organic chemistry
1 We studied the effects of endothelium‐derived relaxing factor (EDRF), bovine retractor penis muscle inhibitory factor and sodium nitroprusside, three stimulants of guanylate cyclase, on the in vitro aggregation of washed human platelets. 2 Platelet aggregation induced either by collagen or by the thromboxane A 2 analogue U46619 was inhibited by all three agents. 3 The anti‐aggregatory effect of each agent was inhibited by haemoglobin. 4 The anti‐aggregatory effect of EDRF was potentiated by superoxide dismutase. 5 These findings are discussed in relation to a potential role for EDRF in haemostasis.