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The role of blood vessels in the bioconversion of leukotrienes in the pig
Author(s) -
Galton Simon A.,
Piper Priscilla J.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11213.x
Subject(s) - leukotriene , bioconversion , chemistry , metabolism , cysteine , medicine , endocrinology , biochemistry , pharmacology , enzyme , biology , asthma , fermentation
1 Porcine pulmonary artery has the ability to convert leukotriene C 4 (LTC 4 ) to LTD 4 and then to LTE 4 . 2 In this vessel, there appears to be no further metabolism beyond LTE 4 . 3 LTC 4 (1 n m ) is converted rapidly to LTD 4 , whereas the conversion of LTD 4 to LTE 4 is somewhat slower. 4 The conversion of LTC 4 to LTD 4 is inhibited by the γ‐glutamyl transpeptidase inhibitor, serine‐borate (45 m m ). 5 The conversion of LTD 4 to LTE 4 is inhibited by the aminopeptidase inhibitor, l ‐cysteine (10 m m ). 6 LTB 4 did not appear to be metabolized by porcine pulmonary artery. 7 These results suggest that the vessel wall may play a role in the early stages of leukotriene metabolism.