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Increase in acetylcholine concentrations in the brain of ‘old’ rats following treatment with pyrithioxin (Encephabol)
Author(s) -
Martin K.J.,
Vyas S.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb11206.x
Subject(s) - acetylcholine , neuroscience , medicine , endocrinology , pharmacology , biology
1 Treatment of old rats, for two to three weeks, with pyrithioxin led to an increase in the levels of endogenous acetylcholine (ACh) in the cortex and the striatum but not in the hippocampus. 2 Pretreatment of old rats with pyrithioxin also increased the resting release and the K + ‐stimulated release of radioactive ACh from brain slices in vitro.