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The effect of GR38032F, novel 5‐HT 3 ‐receptor antagonist on gastric emptying in the guinea‐pig
Author(s) -
Costall Brenda,
Gunning S.J.,
Naylor R.J.,
Tyers M.B.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb10280.x
Subject(s) - metoclopramide , gastric emptying , haloperidol , antagonist , guinea pig , medicine , dopamine antagonist , pharmacology , endocrinology , chemistry , receptor antagonist , receptor , stomach , dopamine , vomiting
The effects of GR38032F a novel, selective and potent 5‐hydroxytryptamine (5‐HT 3 )‐receptor antagonist on gastric emptying in the guinea‐pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose‐dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied.