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Cytoprotective effects of disodium cromoglycate on rat stomach mucosa
Author(s) -
Goossens J.,
Reempts J.,
Wauwe J.P.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb08995.x
Subject(s) - desquamation , cytoprotection , gastric mucosa , stomach , pharmacology , prostaglandin , prostaglandin e , prostaglandin e2 , medicine , chemistry , subcutaneous injection , pathology , oxidative stress
1 The cytoprotective effects of the anti‐asthmatic drug, disodium cromoglycate (DSCG), on gastric mucosal necrosis induced by ethanol in rats were studied. Subcutaneous, but not oral, DSCG prevented the formation of gastric lesions and this effect was dose‐dependent between 1.25 and 40 mg kg −1 , with an ED 50 value of 6.8 mg kg −1 . Maximal cytoprotection occurred 15–30 min after DSCG treatment. 2 Histological examination revealed that DSCG effectively protected the gastric mucosa against ethanol‐induced vascular congestion, haemorrhage, epithelial desquamation and mucosal oedema. 3 Enhanced production of endogenous prostaglandins, which are known cytoprotective compounds, could not explain the mucosal protection. At a dose of 40 mg kg −1 , DSCG did not change prostaglandin E 2 or 6‐keto‐prostaglandin F 1α concentrations in gastric mucosal tissue, although its cytoprotective activity was partially inhibited by prior treatment of the animals with indomethacin.