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The effects of the stable thromboxane A 2 ‐mimetic, U46619, on gastric mucosal damage and gastric non‐parietal secretion in the rat
Author(s) -
Bunce K.T.,
Clayton N.M.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb08979.x
Subject(s) - thromboxane , thromboxane a2 , secretagogue , stomach , medicine , secretion , gastric mucosa , endocrinology , parietal cell , gastric acid , antagonist , endogeny , chemistry , receptor , platelet
1 The effects of the thromboxane A 2 ‐mimetic, U46619, and the thromboxane receptor antagonist, AH23848, on ethanol‐induced gastric mucosal damage and gastric non‐parietal secretion have been examined in the rat. 2 Oral dosing with U46619 or AH23848 produced a dose‐related inhibition of ethanol‐induced gastric mucosal damage in the conscious rat, and these effects were partially blocked by indomethacin treatment. 3 Intragastric application of U46619 or AH23848 to the stomach of the anaesthetized rat stimulated the gastric secretion of a juice which consisted principally of Na + and Cl − ions. These secretagogue effects of both compounds were blocked by indomethacin treatment. 4 These results show that U46619 and AH23848 induce secretory and protective effects in the stomach of the rat, although these responses probably do not involve thromboxane receptors and are mediated, at least in part, by endogenous prostaglandins. 5 The results are discussed in relation to the role of endogenous thromboxane A 2 in gastric mucosal protection, and of the possible protective function of non‐parietal secretion in the stomach.