Premium
Failure of prostaglandin E 2 and its 16,16‐dimethyl analogue to prevent the gastric mucosal damage induced by Paf
Author(s) -
Steel Graham,
Wallace John L.,
Whittle Brendan J.R.
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb08966.x
Subject(s) - gastric mucosa , platelet activating factor , prostaglandin e2 , prostaglandin e , prostaglandin , pharmacology , chemistry , medicine , endocrinology , stomach
1 Intravenous and orally administered prostaglandin E 2 (PGE 2 ) and 16,16‐dimethyl PGE 2 (dm PGE 2 ) protect the rat gastric mucosa from injury induced by oral administration of acidified 40% ethanol. The effects of pretreatment with these prostaglandins on platelet activating factor (Paf)‐induced gastric damage has now been investigated in the rat. 2 A 10 min infusion of Paf (50 or 100 ng kg −1 min −1 , i.v.) resulted in dose‐related vasocongestion of the gastric mucosa. 3 Intravenous pretreatment with dmPGE 2 (20 μg kg −1 ) failed to prevent the gastric damage induced by the higher dose of Paf. Pretreatment with PGE 2 (10–100 μg kg −1 ) or dmPGE 2 (1–20 μg kg −1 ), either orally or intravenously, also failed to prevent the gastric vasocongestion induced by the lower dose of Paf. On the contrary, significant augmentation of Paf‐induced damage was observed with several of the doses of PGE 2 and dmPGE 2 . 4 These studies demonstrate that the protective properties of PGE 2 and dmPGE 2 in the gastric mucosa do not extend to damage induced by Paf.