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Effect of somatostatin on 45 Ca fluxes in guinea‐pig isolated atria
Author(s) -
Díez Juan,
Tamargo Juan
Publication year - 1987
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1987.tb08960.x
Subject(s) - guinea pig , somatostatin , medicine , endocrinology , chemistry , stimulation , biology
1 The effect of somatostatin (SS, 10 −6 m and 5 × 10 −6 m ) was studied on 45 Ca fluxes in guinea‐pig isolated atria. 2 SS produced a dose‐dependent decrease in 45 Ca uptake, this effect being dependent on the stimulation rate and Ca concentration in the bathing media. 3 The decrease in 45 Ca uptake was more evident at faster (60 and 180 beats min −1 ) than at slower frequencies (15 beats min −1 ) and was less evident in high Ca (5.4 m m ). 4 SS had no effect on 45 Ca efflux. 5 These results suggest that SS inhibits the slow inward Ca current in guinea‐pig atrial fibres.