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Effects of OPC‐8212, a new positive inotropic agent, on canine ventricular arrhythmias
Author(s) -
Hashimoto Keitaro,
Mitsuhashi Harumi
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb16266.x
Subject(s) - amrinone , ventricular fibrillation , inotrope , digitalis , medicine , cardiology , ventricular tachycardia , ligation , fibrillation , atrial fibrillation , heart failure
1 OPC‐8212, a positive inotropic agent that increases intracellular cyclic AMP and stimulates the Ca current, was compared with amrinone and AR‐L 115 in their effects on canine ventricular arrhythmias. 2 OPC‐8212, up to 3 mg kg −1 , did not worsen 24 h coronary ligation arrhythmias, while it aggravated ventricular arrhythmias seen 48 h after coronary ligation. However, OPC‐8212 did not at any time induce ventricular fibrillation in dogs subjected to coronary ligation. 3 OPC‐8212, up to 3 mg kg −1 , had no arrhythmogenic or antiarrhythmic effect on digitalis‐induced arrhythmias, while amrinone and AR‐L 115 showed antiarrhythmic effects. 4 With adrenaline‐induced arrhythmias, the three drugs aggravated ventricular tachycardia to produce ventricular fibrillation. 5 The absence of a worsening effect of the new positive inotropic agents on digitalis arrhythmia may be helpful in a clinical setting of combined therapy of these new drugs with digitalis.