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Augmentation by calcium channel antagonists of general anaesthetic potency in mice
Author(s) -
Dolin S.J.,
Little H.J.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb16265.x
Subject(s) - nitrendipine , verapamil , flunarizine , potency , pharmacology , chemistry , calcium channel , calcium , anesthesia , ethanol , medicine , biochemistry , in vitro , organic chemistry
1 The effects of three kinds of calcium channel antagonists on the anaesthetic potencies of ethanol, pentobarbitone and argon were examined in mice. 2 Ethanol and pentobarbitone anaesthetic potencies in mice were significantly increased by verapamil 10 mg kg −1 , flunarizine 40 mg kg −1 and nitrendipine 100 mg kg −1 . 3 Argon anaesthetic potency was significantly increased by nitrendipine 50 mg kg −1 and 100 mg kg −1 in a dose‐related fashion. 4 Even at very high doses the calcium channel antagonists did not produce anaesthesia by themselves. 5 At the doses used the calcium channel antagonists did not affect the blood concentrations of ethanol, 2 h, or pentobarbitone, 15 min, after anaesthetic administration.