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Muscarinic and nicotinic mechanisms in the responses of the adrenal medulla of the dog and cat to reflex stimuli and to cholinomimetic drugs
Author(s) -
Critchley J.A.J.H.,
Ellis P.,
Henderson C.G.,
Ungar A.,
West Christine P.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb11188.x
Subject(s) - nicotinic agonist , adrenal medulla , muscarinic acetylcholine receptor , muscarinic antagonist , endocrinology , medicine , reflex , acetylcholine , nicotinic antagonist , medulla , chemistry , catecholamine , receptor
1 In isolated perfused adrenal glands of the cat, muscarinic and nicotinic agonists selectively released adrenaline and noradrenaline respectively. 2 In isolated perfused adrenal glands of the dog, the output of adrenaline and noradrenaline remained in a fixed ratio at rest and when stimulated by muscarinic or by nicotinic agonists. 3 In the anaesthetized dog, a combination of muscarinic and nicotinic antagonists was needed to block reflex responses of the adrenal medulla. A nicotinic antagonist was more effective in blocking the baroreceptor reflex response than the chemoreceptor reflex response.