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Muscarinic receptor modulation of release of [Met 5 ]enkephalin immunoreactive material and catecholamines from the bovine adrenal gland
Author(s) -
Barron B.A.,
Hexum T.D.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb11175.x
Subject(s) - muscarine , endocrinology , muscarinic acetylcholine receptor , medicine , pilocarpine , methacholine , adrenal medulla , chemistry , acetylcholine , muscarinic acetylcholine receptor m2 , atropine , enkephalin , muscarinic acetylcholine receptor m4 , receptor , catecholamine , biology , opioid , epilepsy , respiratory disease , lung , neuroscience
1 Muscarinic receptor modulation of secretion from the adrenal medulla was studied using retrogradely perfused bovine tissue. 2 Atropine, at a dose not affecting 1,1 dimethyl‐4‐phenylpiperizinium (DMPP)‐stimulated release, inhibitied the acetylcholine (ACh)‐stimulated release of noradrenaline and [Met 5 ]enkephalin‐immunoreactive material (ME‐IRM). 3 DMPP‐stimulated release of catecholamines and ME‐IRM was potentiated by the addition of methacholine. 4 Pilocarpine significantly potentiated the release of noradrenaline only. 5 Methacholine, pilocarpine or muscarine, when infused alone, had no stimulatory affect on the basal release of ME‐IRM. 6 These findings suggest that the muscarinic receptors in the bovine adrenal medulla function by potentiating the release of ME‐IRM and catecholamines induced by nicotinic receptor stimulation.