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Feline endotoxin shock: effects on tissue histamine and histidine decarboxylase activity
Author(s) -
Parratt James R.,
Saleh Samira,
Waton N. Graham
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb11167.x
Subject(s) - histidine decarboxylase , histamine , cats , shock (circulatory) , histidine , carboxy lyases , gastrointestinal tract , lung , pharmacology , chemistry , endocrinology , biology , medicine , biochemistry , enzyme
1 Tissue histamine levels as well as specific and non‐specific histidine decarboxylase were examined before and at various times (5 and 10 min) after the intravenous injection of a lethal dose (2 mg kg −1 ) of E. coli endotoxin in anaesthetized cats. 2 Histamine levels were increased 5 min after endotoxin, especially in the skin, liver, lung and stomach. 3 There was evidence, in most of the cats, for a rapid and substantial activation of specific histidine decarboxylase especially in the lungs, liver, heart and gastrointestinal tract 5–10 min after endotoxin administration. 4 It is suggested that endotoxin induces the local formation of histamine and that this formation and local release may contribute to the pathophysiology of endotoxin shock in this species.