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Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo
Author(s) -
Brage R.,
Cortijo J.,
Esplugues J.,
Esplugues J. V.,
MartíBonmatí E.,
Rodriguez C.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb11166.x
Subject(s) - verapamil , diltiazem , cinnarizine , calcium channel , gastric acid , gastric emptying , medicine , calcium , endocrinology , chemistry , secretion , pharmacology , stomach
1 Experiments were designed to evaluate the effects of three calcium channel blockers (verapamil, diltiazem and cinnarizine) on gastric emptying and secretion in the rat 2 Pretreatment with the calcium blockers delayed gastric emptying of phenol red in a dose‐dependent manner. Verapamil was the most effective of the agents tested. 3 Verapamil and diltiazem inhibited gastric acid secretion in the pylorus‐ligated rat without affecting pepsin output. Cinnarizine was ineffective in this model. 4 When the perfused lumen of the anaesthetized rat was used, verapamil was found to inhibit responses to carbachol or histamine more than those to pentagastrin. Further, we found a greater sensitivity to verapamil for basal compared with vagal‐stimulated (2‐deoxy‐D‐glucose) acid secretion. Neither diltiazem nor cinnarizine modified gastric acid secretion in this experimental model. 5 These findings are discussed in relation to the role of extracellular calcium in gastric motility and secretion, and the existence of a regional and functional selectivity for calcium blockers is proposed.