Premium
Postsynaptic α 1 ‐ and α 2 ‐adrenoceptors in the vascular system of the herring gull, Larus argentatus
Author(s) -
Hermansson LarsErik,
Johansson Pehr
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb11143.x
Subject(s) - rauwolscine , prazosin , yohimbine , larus , phenylephrine , clonidine , medicine , endocrinology , alpha 2 adrenergic receptor , herring , alpha (finance) , antagonist , biology , chemistry , blood pressure , fishery , receptor , construct validity , nursing , fish <actinopterygii> , patient satisfaction
1 The nature of the vascular α‐adrenoceptors has been studied in the herring gull, Larus argentatus.2 In the anaesthetized herring gull, both phenylephrine and clonidine elicited dose‐dependent increases in arterial blood pressure. 3 The α 1 ‐adrenoceptor antagonist prazosin was a better antagonist of phenylephrine than were the α 2 ‐adrenoceptor antagonists yohimbine and rauwolscine. 4 Yohimbine and rauwolscine were better antagonists of clonidine than was prazosin. 5 The maximum response to phenylephrine, but not clonidine, was lower in reserpine‐treated birds, indicating that phenylephrine in high doses liberates endogenous catecholamines, which contribute to the effect. 6 It is concluded that the herring gull possesses postsynaptic, vascular α‐adrenoceptors, of both the α 1 ‐ and α 2 ‐subtypes, similar to those found in mammals.