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Effects of an increase in haemoglobin O 2 affinity produced by BW12C on myocardial function in the erythrocyte‐perfused rabbit heart in vitro and myocardial infarct size in the dog
Author(s) -
Allan G.,
Chapple D. J.,
Hughes B.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb11134.x
Subject(s) - perfusion , coronary perfusion pressure , medicine , ventricular pressure , hemodynamics , cardiology , coronary circulation , cardiac output , cardiac function curve , oxygenation , chemistry , lagomorpha , heart rate , blood flow , blood pressure , anesthesia , heart failure , resuscitation , cardiopulmonary resuscitation
1 The effects of BW12C on myocardial function in the erythrocyte‐perfused rabbit heart and on myocardial infarct size in the anaesthetized dog have been evaluated. 2 Perfusion of rabbit hearts with erythrocytes pretreated with BW12C (10 −3 M‐4× 10 −3 M) produced concentration‐dependent decreases in left ventricular pressure (LVP), LVP dP/dt and coronary perfusion pressure. A concomitant decrease in P O 2 and an increase in lactate production by the myocardium was also observed. 3 Perfusion of rabbit hearts with Krebs Henseleit buffer containing BW12C (10 −5 − 10 −4 M) caused no change in measured variables. Although BW12C (10 −3 M) caused a small decrease in LVP, coronary perfusion pressure and heart rate, these changes were not significant. 4 In anaesthetized dogs, an infusion of BW12C (total dose 50 mg kg −1 , i.v.) caused small, but significant, changes in haemodynamic status. The oxygen saturation curve was shifted to the left and relative % oxygenation (P 20 ) was shifted to the left throughout the course of the experiment. (P 20 , control 16.3 ± 0.4 mmHg; after BW12C 7.9 ± 1.4 mmHg). 5 Pretreatment with BW12C (total dose 50 mg kg −1 ) caused no change in area at risk but significantly increased the myocardial infarct size by 410%. 6 These studies with BW12C demonstrate that alteration in haemoglobin‐oxygen affinity can induce adaptive physiological changes in tissue function and metabolism and can assume a critical role when oxygen supply may be impaired due to a flow‐limiting stenosis.