Premium
Attenuation by isosorbide dinitrate of coronary occlusion‐induced acidosis in the dog myocardium
Author(s) -
Abiko Yasushi,
Fukushi Yukio,
Haga Naomi,
Matsumura Hisao
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10833.x
Subject(s) - isosorbide dinitrate , medicine , cardiology , occlusion , acidosis , coronary occlusion , anesthesia , saline , blood flow , fissipedia
1 In dogs anaesthetized with pentobarbitone, the thorax was opened and myocardial pH measured continuously by the use of a glass pH electrode inserted in the left ventricular wall. 2 The left anterior descending coronary artery (LAD) was partially occluded so that the LAD flow could be reduced to a half or one‐third of the original flow (partial occlusion). LAD partial occlusion was continued for 90 min, drug or saline being infused for the last 60 min of this period. 3 LAD occlusion decreased myocardial pH significantly by 0.41 to 0.67 pH units, and increased ST segment of the surface electrocardiogram from 11.7 to 12.1 mV. 4 In dogs with non‐ischaemic normal hearts, isosorbide dinitrate (ISDN; 1 mg kg −1 ) did not change markedly either the LAD flow, myocardial pH or heart rate, whereas it decreased myocardial contractile force (determined by a strain gauge arch) slightly and both the systolic and diastolic blood pressure markedly. 5 In dogs with partial LAD occlusion, ISDN (1 mg kg −1 ) increased myocardial pH significantly and decreased blood pressure, but did not change ST segment elevation in an epicardial lead. 6 These results indicate that ISDN attenuates ischaemia‐induced acidosis without attenuating ischaemia‐induced ST elevation in the dog myocardium.