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Central β‐adrenoceptors can modulate 5‐hydroxytryptamine‐induced tremor in rats
Author(s) -
Hallberg Heléne
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10830.x
Subject(s) - agonist , clenbuterol , antagonist , carbidopa , endocrinology , chemistry , medicine , pargyline , pharmacology , metoprolol , beta (programming language) , receptor , serotonin , levodopa , programming language , disease , parkinson's disease , computer science
1 The effects of two β 2 ‐adrenoceptor agonists with different lipophilicities were studied on tremor induced by L‐5‐hydroxytryptophan (L‐5‐HTP) in pargyline‐ and carbidopa‐pretreated rats. 2 Tremor was recorded and analysed by an objective method based on accelerometry. 3 Clenbuterol, a lipophilic β 2 ‐selective agonist, dose‐dependently enhanced tremor intensity, whereas the hydrophilic β 2 ‐agonist terbutaline had no effect. 4 The clenbuterol‐induced enhancement of tremor was completely abolished by the β 2 ‐selective antagonist ICI 118,551 but unchanged by the β 1 ‐selective antagonist metoprolol. 5 The results suggest that centrally located β 2 ‐adrenoceptors can mediate a modulation of 5‐hydroxytryptamine‐induced tremor in rats.