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The inhibitory action of 5‐hydroxytryptamine on gastric secretory function in rats
Author(s) -
Cho C.H.,
Ogle C.W.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10826.x
Subject(s) - inhibitory postsynaptic potential , action (physics) , function (biology) , neuroscience , pharmacology , medicine , chemistry , biology , microbiology and biotechnology , physics , quantum mechanics
1 The inhibitory action of 5‐hydroxytryptamine (5‐HT) on gastric function was studied in vagotomized rats. 2 5‐HT (0.6, 1 or 5 mg kg −1 , s.c.) dose‐dependently reduced gastric acid secretion evoked by histamine, pentagastrin or methacholine. Pepsin secretion induced by pentagastrin or methacholine was also depressed by 5‐HT. 3 Basal secretion of both acid and pepsin was not significantly affected by any of the three 5‐HT doses. 4 Indomethacin pretreatment, which significantly decreased gastric mucosal prostaglandin E 2 content, did not modify the inhibitory effects of 5‐HT on histamine‐induced acid secretion, nor did phentolamine or propranolol. 5 This study suggests that 5‐HT inhibits gastric secretory function through mechanisms other than by sympathetic influence or increased prostaglandin synthesis. The inhibitory action appears not to be vagus‐dependent. Other mechanisms of action are discussed.