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Kadsurenone distinguishes between different platelet activating factor receptor subtypes on macrophages and polymorphonuclear leucocytes
Author(s) -
Lambrecht Günter,
Parnham Michael J.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10816.x
Subject(s) - polymorphonuclear leukocyte , platelet , receptor , chemistry , platelet activating factor , immunology , microbiology and biotechnology , biology , biochemistry , in vitro
The effects of the antagonist kadsurenone on the platelet activating factor (Paf)‐induced chemiluminescence of guinea‐pig peritoneal macrophages and on pig peripheral blood leucocyte aggregation were compared. Linearity and slopes of unity of the Schild plots confirmed the competitive nature of the antagonism by kadsurenone. pA 2 values indicated a 91 fold lower affinity of kadsurenone for leucocyte Paf receptors than for those in macrophages. It is concluded that these two types of Paf receptors are not identical and are provisionally designated Paf 1 and Paf 2 receptors, respectively.