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Effects of α‐adrenoceptor agonists and antagonists on ouabain‐induced arrhythmias and cardiac arrest in guinea‐pig
Author(s) -
Thomas George P.,
Tripathi Rajit M.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10271.x
Subject(s) - ouabain , yohimbine , phenylephrine , prazosin , blockade , stimulation , ventricular fibrillation , pharmacology , medicine , agonist , receptor , endocrinology , guinea pig , chemistry , antagonist , sodium , blood pressure , organic chemistry
1 Effects of α‐adrenoceptor agonists and antagonists with different affinity for α 1 ‐ and α 2 ‐receptors on ouabain‐induced arrhythmias in guinea‐pigs were studied. 2 Early arrhythmias, ventricular fibrillation and cardiac arrest were induced in anaesthetized guinea‐pigs by the slow intravenous infusion of ouabain. 3 Phenylephrine and yohimbine potentiated the cardiotoxicity of ouabain significantly whereas prazosin and clonidine showed significant antiarrhythmic effects and delayed the cardiac arrest. 4 It is concluded that selective α 1 ‐receptor stimulation and α 2 ‐receptor blockade increases the cardiotoxic effects of ouabain and selective α 2 ‐receptor stimulation and α 1 ‐receptor blockade inhibits ouabain‐induced arrhythmias and cardiac arrest in guinea‐pigs.