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The effect of α 2 ‐adrenoceptor agonists on the acid secretory responses of rat isolated gastric mucosa to electrical field stimulation
Author(s) -
Dettmar P.W.,
Lord J.A.H.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10268.x
Subject(s) - prazosin , phenylephrine , stimulation , endocrinology , medicine , clonidine , idazoxan , gastric mucosa , cholinergic , agonist , guanabenz , adrenergic receptor , gastric acid , chemistry , alpha (finance) , stomach , receptor , antagonist , blood pressure , construct validity , nursing , patient satisfaction
1 The effects of clonidine, UK‐14,304, noradrenaline, para ‐aminoclonidine and phenylephrine were examined on the acid secretory response of the rat isolated gastric mucosa preparation to electrical field stimulation. 2 Clonidine, UK‐14,304, noradrenaline and para ‐aminoclonidine but not phenylephrine (10 μM) reduced the response of the gastric mucosa stimulated at 2.5 Hz; gastric mucosae stimulated at higher frequencies were insensitive to the action of these α 2 ‐adrenoceptor agonists. 3 The inhibitory effect of the selective α 2 ‐adrenoceptor agonist UK‐14,304 was antagonized by idazoxan but not by prazosin. 4 These findings indicate that clonidine and other α 2 ‐adrenoceptor agents inhibit the acid secretory response of the rat gastric mucosa to electrical field stimulation by an action at α 2 ‐adrenoceptors, which are probably located on cholinergic nerve terminals.