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Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice
Author(s) -
Sandström PerErik
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10261.x
Subject(s) - probenecid , diuresis , furosemide , diuretic , natriuresis , chemistry , endocrinology , pharmacology , medicine , kidney
1 The effect of probenecid on frusemide‐induced diuresis and hyperglycaemia was studied in mice. 2 Probenecid, a known inhibitor of tubular secretion of organic anions in the kidney, strongly reduced the diuretic response to frusemide (25 or 200 mg kg −1 body weight). This effect of probenecid appeared to be dose‐dependent up to 240 mg kg −1 body weight, at least at the lower concentration of frusemide. 3 Pretreatment with probenecid (240 mg kg −1 body weight) potentiated the hyperglycaemic effect of frusemide (25 or 200 mg kg −1 body weight). 4 The results show that probenecid has opposite effects on frusemide‐induced diuresis and hyperglycaemia in mice. It is suggested that the acute hyperglycaemic effect of frusemide is not directly linked to diuresis.