Premium
The hypothermic action of carbachol in the rat brain periaqueductal grey area may involve neurotensin
Author(s) -
Griffiths E.C.,
Slater P.,
Widdowson P.S.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10247.x
Subject(s) - carbachol , neurotensin , hypothermia , endocrinology , medicine , periaqueductal gray , neurotransmitter , atropine , chemistry , neuropeptide , pharmacology , central nervous system , receptor , midbrain
1 Neurotensin (NT) and carbachol both caused hypothermia when injected into the periaqueductal grey area (PAG) of rat brain. 2 Atropine prevented carbachol‐ but not NT‐induced hypothermia. 3 NT‐induced hypothermia was unaffected by various neurotransmitter agonists and antagonists in the PAG. 4 Both NT antibodies and thyrotrophin releasing hormone prevented carbachol hypothermia. 5 It is concluded that the hypothermic action of carbachol in the PAG is mediated via endogenous NT.