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Urinary kallikrein excretion during inhibition of endogenous angiotensin II in the pig
Author(s) -
Binder Bernd R.,
Maier Manfred,
Rana Hemanta,
Starlinger Michael,
Zhegu Zydi
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10237.x
Subject(s) - saralasin , endocrinology , medicine , angiotensin ii , kallikrein , renin–angiotensin system , urinary system , kinin , excretion , renal blood flow , chemistry , renal function , blood pressure , bradykinin , receptor , biochemistry , enzyme
1 This study was performed to assess the possible contribution of endogenous angiotensin II (AII) to the regulation of urinary kallikrein excretion. The AII antagonist saralasin or the saline vehicle was infused into the aorta above the renal arteries of pigs under halothane‐O 2 /N 2 O anaesthesia. Systemic and renal functional parameters were followed for 140 min and during stimulation of the renin‐angiotensin system by haemorrhage. 2 Urinary kallikrein excretion, determined as kininogenase activity, was increased immediately upon both initiation and termination of the 2 h saralasin infusion into pigs not subjected to haemorrhage. Renal cortical blood flow (RCBF) was maintained in both saline and saralasin‐treated animals at blood pressures as low as 70 mm Hg, while glomerular filtration rate was dissociated during saralasin infusion. As long as RCBF was maintained, urinary kallikrein excretion rate was elevated during the progressive hypotension in both saline and saralasin‐treated animals. 3 These findings confirm a close relationship between the maintenance of RCBF and increased activity of the kallikrein‐kinin system whether or not AII is antagonized, and indicate that during haemorrhage the kallikrein‐kinin system is stimulated by a mechanism not involving AII.