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Pharmacological investigation into the effects of histamine and histamine analogues on guinea‐pig and rat colon in vitro
Author(s) -
Aguilar MaríaJosé,
MoralesOlivas Francisco J.,
Rubio Elena
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10229.x
Subject(s) - histamine , prazosin , guinea pig , cimetidine , histamine receptor , endocrinology , medicine , histamine h1 receptor , pharmacology , histamine h2 receptor , chemistry , mepyramine , histamine h1 antagonists , hexamethonium , antagonist , atropine , biology , receptor
1 The effects of histamine and specific histamine agonists has been examined on isolated longitudinal colon strips of guinea‐pig and rat. 2 Histamine and 2‐pyridyl‐ethylamine but not 4 methylhistamine produced a concentration‐related contractile response in the guinea‐pig colon. 3 The H 1 ‐antagonist clemizole antagonized competitively the effect of histamine but the H 2 ‐antagonist ranitidine did not modify the dose‐response curve to histamine in the guinea‐pig colon. 4 Atropine, hexamethonium, prazosin and propranolol failed to modify the contractile response to histamine. 5 Tone induced with KCl in guinea‐pig isolated colon was not modified by histamine agonists even in tissues pretreated with clemizole or ranitidine. 6 Histamine and histamine analogues were without effect on the isolated longitudinal strip of the rat colon. 7 It is concluded that histamine produced dose‐dependent contractions of the guinea‐pig colon due to direct activation of H 1 ‐histamine receptors. There is no evidence in favour of the existence of H 2 ‐histamine receptors in this preparation. The lack of effect of histamine agonists in rat colon strip argues against the existence of histamine receptors in this preparation.