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Pilot experiments on the actions of drugs injected into the human corpus cavernosum penis
Author(s) -
Brindley G.S.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10191.x
Subject(s) - phentolamine , phenoxybenzamine , papaverine , guanethidine , verapamil , tolazoline , reserpine , medicine , penis , prazosin , endocrinology , propranolol , anesthesia , anatomy , stimulation , receptor , antagonist , calcium
1 Seven drugs that are known to relax smooth muscle (phenoxybenzamine, phentolamine, thymoxamine, imipramine, verapamil, papaverine, naftidrofuryl) caused erection when injected intracavernosally. 2 Salbutamol, hydralazine, lignocaine and bupivacaine caused tumidity but not erection. 3 Metaraminol and guanethidine caused shrinkage followed by tumidity. 4 Neostigmine, atropine, propranolol and idazoxan had no effect in the doses tried. 5 It is argued that the seven drugs that cause erection do so by relaxing vascular and trabecular smooth muscle within the cavernosal space, and that the two that cause shrinkage of the penis do so by constricting vascular and trabecular smooth muscle within the cavernosal space. 6 It is argued that muscarinic and β‐adrenergic transmission play no important part in erectile mechanisms within the corpora cavernosa. 7 Papaverine, phenoxybenzamine and metaraminol, given intracavernosally, are already used therapeutically. Uses are suggested for thymoxamine, phentolamine, verapamil and guanethidine.