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Naloxone inhibits arrhythmias induced by coronary artery occlusion and reperfusion in anaesthetized dogs
Author(s) -
Huang X.D.,
Lee A.Y.S.,
Wong T.M.,
Zhan C.Y.,
Zhao Y.Y.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10186.x
Subject(s) - medicine , ventricular fibrillation , cardiology , coronary occlusion , anesthesia , (+) naloxone , occlusion , ventricular tachycardia , myocardial infarction , fibrillation , opioid , atrial fibrillation , receptor
The intravenous administration of naloxone 2 min before coronary artery occlusion in anaesthetized dogs reduced the incidence and severity of cardiac arrhythmias during coronary occlusion (20 min) and reperfusion (120 min) in a dose‐related manner. It also reduced the mortality. At a dose of 1 mg kg −1 (the maximum dose used in this study) naloxone abolished the appearance of the life threatening ventricular fibrillation (VF) and ventricular tachycardia (VT) and as a consequence all dogs in this group survived. The results suggest a possible involvement of endogenous opioid peptides in arrhythmogenesis during coronary occlusion and reperfusion in the dog.