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Non involvement of γ‐aminobutyric acid in catechol‐induced seizures
Author(s) -
Dewhurst D.G.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10168.x
Subject(s) - convulsant , diazepam , anticonvulsant , pharmacology , chemistry , phenobarbital , aminobutyric acid , anesthesia , epilepsy , neuroscience , medicine , biochemistry , psychology , receptor
1 The effects of certain anticonvulsant agents, namely, vaproate, diazepam and phenobarbitone were investigated on catechol‐induced spontaneous and evoked convulsions, in anaesthetized rats and mice. 2 Valproate and diazepam significantly reduced the intensity of spontaneous convulsions and the frequency of occurrence of the longer‐latency components (M2 and M3) of the evoked muscle response. 3 Phenobarbitone significantly reduced spontaneous convulsions and the M3 component of the evoked muscle response. 4 None of the drugs affected the short latency M1 component indicating a supra‐spinal site of action of these drugs. 5 Agents which modify γ‐aminobutyric acid (GABA)‐mediated transmission were without effect on the frequency of occurrence of M1, M2 or M3. 6 The results suggest that the convulsant action of catechol is not dependent on antagonism of GABA‐mediated inhibition.