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The roles of prostaglandin endoperoxides, thromboxane A 2 and adenosine diphosphate in collagen‐induced aggregation in man and the rat
Author(s) -
Emms H.,
Lewis G.P.
Publication year - 1986
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1986.tb10162.x
Subject(s) - adenosine diphosphate , thromboxane , chemistry , platelet aggregation , platelet , agonist , medicine , aspirin , endocrinology , prostaglandin , thromboxane a2 , creatine kinase , adenosine , biochemistry , receptor , biology
1 The effects of aspirin, carboxyheptylimidazole (CHI) and creatine phosphate/creatine phosphokinase (CP/CPK) on platelet aggregation and thromboxane B 2 (TxB 2 ) formation induced by collagen have been examined in vitro. Platelets from two species, man and the rat, have been used. 2 In man, aspirin and CHI abolished TxB 2 production but only partially inhibited aggregation. CP/CPK partially inhibited aggregation and TxB 2 formation. 3 In the rat, aspirin and CHI abolished TxB 2 formation but had no effect on aggregation. CP/CPK completely inhibited aggregation and partially inhibited TxB 2 generation. 4 In man, collagen‐induced aggregation is largely dependent on ADP and to a lesser extent on arachidonate metabolites whereas, in the rat, ADP alone mediates aggregation induced by this agonist. 5 The results with CP/CPK suggest that TxB 2 formation is dependent either on the prior release of platelet ADP or on aggregation itself rather than being responsible for the aggregation response.